నైరూప్య

Effect of Ginger Extract Consumption On Renal Function during Ethanol Withdrawal Induced-Stress

Swaroopa Maralla

From times unknown, ginger has become a subject of interest because of its beneficial effects on human health. The purpose of the present study was to investigate the effects of daily oral administration of ginger extract for 6 weeks on kidney functions in withdrawal rats to evaluate the ameliorating effects in alcohol induced-withdrawal rats. Rats (130-150gm) were divided into 4 groups; normal control rats, alcoholic control rats, ethanol withdrawal rats and ethanol withdrawal rats pretreated with ginger. Ginger extract was administered orally for 6 weeks to pre-treated rats, and they were compared with the normal and alcoholic groups, respectively. The treatment with ginger extract had significant effect on Plasma Electrolyte Profiles. Low plasma sodium level and increased plasma potassium levels were observed in ginger pretreated ethanol withdrawal group. The plasma creatinine, urea and uric acid levels were significantly reduced in this group compared to alcoholic control rats and ethanol withdrawal rats. It is concluded that the consumption of ginger produced a significant anti- nephrotoxic effect in ethanol withdrawal rats. In addition, ginger is showing properties of anti-hypertensive drugs and is capable of improving impaired kidney function in ethanol withdrawal rats.