నైరూప్య

Graphical Model of Genes: A Review

Maity Sheuli, Maiti Krishna Kanta, Ghosh Sagarika

Gene is the regulator of the genotype and phenotype of an organism. Presence of one or more Gene mutation or some environmental factors result the variance in Expression level that creates Differentially Expressed Gene (DEGs), which can cause the predisposition or susceptibility to a particular disease. The most challenging issue for the modern geneticists is to discover and understand the function and variation of Genes interconnecting between themselves and other environmental factors; as well as to understand how such qualities affect health and disease. To differentiate between normal Gene and DEGs, researchers have suggested various Graphical Modeling approach using Probabilistic, Statistical and Graph theory methodology.