నైరూప్య

Green Synthesis of AgNP?S Using Alternanthera Sessilis Leaf Extract [A Natural Source for Ocular Therapy]

D Sarvamangala, Kantipriya Kondala, U S N Murthy, B Narasinga Rao, N Sivakumar

The present day drug market is almost inundated with a plethora of eye drops and eye ointments to answer prescriptions for curing ocular diseases. A path breaking and innovative thinking is towards employing silver nanoparticles (AgNP’S) effectively and advantageously for sustained drug delivery system, in the prophylactic as well as curative treatment of ophthalmic indispositions. In this present work, silver nanoparticles obtained through leaf extract of Alternanthera sessilis (A.sessilis) presented a size of 3 to 50 nm and were round in shape. Particles thus obtained were subjected to various series of tests viz. UV-Visible Absorption Spectroscopy (UV-Vis), X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), Energy Dispersive Spectroscope (EDS), Particle Size Analysis (PSA) and Transmission Electron Microscope (TEM) analysis. It is observed that the synchronous action of AgNP’S assures prevention as well as eradication of ocular pathogens bereft of any side effect and identified the synergetic activity of silver nanoparticles against ocular pathogens. Besides, drugs developed by using silver nanoparticles, have specific biological targets such as replicative, synthetic or metabolic enzymes which are unique to disease causing microbes and can be safely introduced into living tissues. Plentiful evidence is available to assert that plenitude of protection against ocular pathogens is provided by AgNP’S, adequately safeguarding intraocular efficacy. The rationale behind the application of silver nanoparticles (AgNP’S) against eye pathogens is – it is cost effective and eco-friendly. Research work on silver nanoparticles against eye pathogens will provide an answer to prevent devastating sight – threatening pathogenic complications in the eye.