నైరూప్య

Understanding the Pathophysiological Basis of Alterations of Hematological Picture in Alcohol Abuse Patients

Arjun Maitra and Chaitali Maitra

Alcohol abuse disorder is a major health related problem. Almost all organs is affected by the alcohol ingestion. Peripheral blood smear usually provides significant information regarding diagnosis and prognosis of a disease. Objective of our study was to determine impairment of hematological system in non cirrhotic alcohol abuse disorder patients compared to the normal subjects. Hematological parameters were investigated in 120 subjects including 30 normal control and 90 alcoholics. Study shows significant changes in WBC status. Total leukocyte count is significantly elevated in heavy drinkers. Significant increase in neutrophil count is observed in moderate (11%) and high (18%) alcohol intake group (p < 0.05). Lymphocytes and Monocytes decrease significantly in moderate to heavy drinkers. Our study shows that Eosinophil does not show significant changes among the groups. ESR was found to be increased significantly in alcoholics and shows a strong negative correlation (r = - 0.89) with hemoglobin.